Sunday, January 17, 2010

How to determine adverse drug reactions

Adverse drug reaction, that is "qualified drugs" in the normal use of adverse reactions arising in the process. How to determine adverse drug reactions?
1, suspected adverse reactions occur, first, to see whether the drug description stated, if you have a clear indication, then the more likely.
2, according to chronological order to determine the medication.
1, occurred within a few seconds to a few minutes: If there is to do skin test, the needle has not yet pulled out, i.e. an allergic reaction occurs, the patient soon heartburn, throat hair tight, chest tightness, palpitation, pale, thin and delicate pulse, blood pressure down, and even delirium, requiring immediate rescue.
2, occurred within a few minutes to a few hours: If the fixity erythema frequently occurred in the same position, was purple-red round or oval, often blisters, accompanied by fever and other symptoms.
3, in the half an hour to two hours, took place: such as nausea, vomiting, abdominal pain and other symptoms.
4, 1 ~ 2 weeks after treatment has occurred: such as erythema multiforme after treatment often occurs 2 to 7; exfoliative dermatitis, bullous skin lax drug eruption took place mostly in the 10 in the future; digitalis-induced edema response and diuretics is also more in 1 ~ 2 weeks later.
5, after stopping a long time to occur: If the streptomycin caused deafness, often 6 months after stopping there. Anticancer drug busulfan lung disease often caused by more than 1 year after treatment only appeared. Chloramphenicol, phenylbutazone induced aplastic anemia had a similar situation.
3, depending on the symptoms judged. In general, adverse drug reactions is different from the original symptoms of the disease, such as aspirin, anti-inflammatory pain caused by asthma, gentamicin, streptomycin, caused by deafness, as well as penicillin, iodine preparations, etc. Stuffed percent of anaphylactic shock. But there are also the same individuals, such as clonidine, methyl dopa and other blood pressure medicines, if the long-term application suddenly disabled, can cause sudden jump in blood pressure, heart rate acceleration, or even intracranial hemorrhage, requiring immediate rescue; and if hastily out experience Security, for angina patients before treatment can cause more severe than the symptoms, often at night suddenly, and causing coronary insufficiency, or even severe myocardial infarction, there is the risk of death.
Fourth, whether there is the phenomenon of re-excitation. Namely, whether it will happen again, the same response to medication.
Occurrence of adverse drug reactions should be the timely adoption of a doctor, pharmacist or directly to the Adverse Drug Reaction Monitoring of departmental reports and carry out drug counseling, in order to avoid recurrence. Event of a serious adverse drug reactions should be timely medical treatment

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